Rank Every Longevity Intervention by Years Gained

Stacking Years aggregates peer-reviewed research and expert consensus to rank 55 longevity interventions by their estimated impact on life expectancy. From exercise and nutrition to pharmaceuticals and supplements, every intervention is scored using a transparent methodology: 85% scientific evidence weight and 15% expert consensus weight.

The most impactful interventions include strength training, Zone 2 cardio, Mediterranean diet, sleep optimisation, and smoking cessation. Explore the full rankings, build a personalised longevity programme, and compare how leading experts like Peter Attia, Andrew Huberman, and David Sinclair approach each intervention.

Longevity intervention rankings

Evidence scores combine scientific evidence and expert consensus. Life-expectancy gains are estimates, not guaranteed outcomes, and should not be added together.

All 61 interventions in evidence-score order
RankInterventionEvidence scoreEstimated life-expectancy gain
1150+ min Zone 2 cardio weekly100%+3.3 yrs
2Resistance training 2-3x/week100%+2.5 yrs
3Maintain healthy weight (BMI 18.5-25)100%+2.5 yrs
4Mediterranean diet100%+2.5 yrs
5Avoid ultra-processed foods100%+2.3 yrs
67-9 hours quality sleep100%+2.0 yrs
7Vaccination (Shingrix / latent viral burden)100%+1.5 yrs
8Avoid smoking100%+1.3 yrs
9Nattokinase supplementation100%+1.0 yrs
10Tadalafil (daily low-dose)100%+0.8 yrs
11Astaxanthin100%+0.6 yrs
12Time-restricted eating98%+1.5 yrs
13Metformin (off-label)97%+1.5 yrs
14Limit saturated fat intake96%+1.5 yrs
15Urolithin A (mitochondrial)96%+1.0 yrs
16Brief vigorous lifestyle activity (VILPA)92%+2.2 yrs
17Quercetin (senolytic)89%+1.5 yrs
18Morning sunlight exposure86%+1.3 yrs
19Omega-3 fatty acids (EPA/DHA)85%+1.8 yrs
20Sauna 4x/week83%+2.3 yrs
21HIIT training 1-2x/week83%+2.0 yrs
22Magnesium supplementation83%+1.3 yrs
23Hyperbaric oxygen therapy (HBOT)83%+1.0 yrs
24CoQ10 supplementation81%+0.8 yrs
25Berberine supplementation80%+1.0 yrs
26Glycine/Collagen supplementation80%+1.0 yrs
27Maintain dental health80%+0.8 yrs
28Limit alcohol consumption79%+1.5 yrs
29Strong social connections79%+1.5 yrs
30Lactoferrin79%+0.8 yrs
31Creatine supplementation77%+1.0 yrs
32Methylene blue (low-dose)77%+0.8 yrs
33Red light therapy77%+0.8 yrs
34Adequate hydration77%+0.5 yrs
35Regular health screenings75%+1.0 yrs
36Vagus nerve stimulation75%+0.8 yrs
37Limit added sugar intake72%+2.0 yrs
38Testosterone optimization72%+1.3 yrs
39Hydrogen-Rich Water70%+0.7 yrs
40Flexibility and mobility work68%+1.3 yrs
41Captopril (ACE inhibitor)68%+1.0 yrs
42Whole-body vibration therapy68%+0.8 yrs
43BPC-157 / TB-500 peptides68%+0.8 yrs
44Fisetin (senolytic)67%+1.5 yrs
45GLP-1 agonists (semaglutide)66%+2.0 yrs
46Daily meditation/stress management66%+1.3 yrs
47CGM-guided nutrition65%+1.0 yrs
48Acarbose (ITP longevity)64%+1.0 yrs
49Epitalon + Pinealon peptides64%+0.7 yrs
50Rapamycin + Acarbose combination61%+3.3 yrs
51Rapamycin + Acarbose combination (ITP)61%+3.3 yrs
52Adequate protein intake (1.2-2g/kg)61%+1.5 yrs
53NMN/NR (NAD+ precursors)60%+1.5 yrs
54Canagliflozin (SGLT2 inhibitor)60%+1.0 yrs
55Canagliflozin (ITP longevity)60%+1.0 yrs
56Vitamin D optimization60%+0.8 yrs
57Cold exposure (cold plunge)56%+1.0 yrs
58Rapamycin (experimental)48%+1.8 yrs
5917-Alpha-Estradiol (ITP)46%+1.3 yrs
6017-Alpha-Estradiol (males)46%+1.3 yrs
61Vitamin C + E supplementation42%+0.4 yrs